The consequences
of hyperkalaemia
Hyperkalaemia is unpredictable, may often reoccur, and the consequences may be life-threatening.1,2
This website provides healthcare professionals (HCPs) with information on the impact of hyperkalaemia in these high-risk patients, including the effect on RAASi (renin-angiotensin-aldosterone system inhibitors) dosing and clinical outcomes
References:
This site is for non-US, non-UK healthcare professionals only.
References:
- Thomsen RW et al. Nephrol Dial Transplant. 2017: 1–10. [Epub ahead of print]
- UK Renal Association Clinical Practice Guidelines. 2014. Treatment of Acute Hyperkalaemia in Adults.

Chronic
kidney disease
Hyperkalaemia can be a recurrent problem in patients with CKD, which is associated with an increased risk of hospitalisation*1 and mortality.**2
References
*Compared to matched cohorts without hyperkalaemia.
**Compared to a normokalaemia range K+≥3.5-5 mEq/L.
References:
- Thomsen RW et al. Nephrol Dial Transplant. 2017: 1–10.
- Qin L, et al. ERA-EDTA, Madrid, 2017. Poster presentation MO067.

Heart failure
Hyperkalaemia is common in patients with heart failure, which can prevent patients achieving guideline recommended RAASi.1-3
References:
*RAASi, renin-angiotensin-aldosterone system inhibitors
References:
- Nilsson E, et al. ERA-EDTA, Madrid, 2017. Poster presentation SP313.
- Epstein M et al. Am J Manag Care 2015; 21: S212-S220.
- Maggioni AP et al. Eur J Heart Fail. 2013; 15: 1173-84.

Co-morbid
conditions
Some co-morbid conditions increase a patient’s risk of developing hyperkalaemia, which is associated with poor clinical outcomes.1,2
References:
- Thomsen RW et al. Nephrol Dial Transplant. 2017: 1–10. [Epub ahead of print]
- Qin L, et al. ERA-EDTA, Madrid, 2017. Poster presentation MO067.

RAASi therapy
Hyperkalaemia and subsequent suboptimal RAASi treatment is associated with increased morbidity and mortality. *1
References:
*Compared to optimal RAASi treatment
RAASi, renin-angiotensin-aldosterone system inhibitors
References:
- Epstein M et al. Am J Manag Care 2015; 21: S212-S220.
There is a need for
additional treatment
options for the management
of hyperkalaemia.1
Click the links below to discover the impact of
hyperkalaemia on patients with different conditions.
References:
- National Kidney Foundation. 2014. Clinical update on hyperkalaemia.